Im running into a similar problem with the same external drive. I attempted the same solution, but it didnt help: When I tried to do a backup manually, it failed even sooner.
I wanted to post the two logs that SD! created (one for each attempt), but for some reason, the site wasnt responding earlier today. (Other sites were available, so I can only assume there was a connection problem specific to shirt-pocket.com.)
Here are the two logs:
First (scheduled) backup attempt:
| 01:10:42 PM | Info | SuperDuper!, 2.6.2 (87), path: /Applications/SuperDuper!.app, Mac OS 10.6.4 build 10F569 (i386)
| 01:10:42 PM | Info | Started on Tue, Jul 13, 2010 at 1:10 PM
| 01:10:42 PM | Info | Source Volume: Nick's HD, mount: /, device: /dev/disk0s2, media: ST31000528ASQ, interconnect: Internal SATA, file system: "Journaled HFS+", OS: 10.6.4 (10F569), capacity: 999.86 GB, used: 573.69 GB, directories: 135399, files: 2497090, ejectable: NO, ACLs: Enabled
| 01:10:42 PM | Info | Target Volume: LaCie d2 Quadra, mount: /Volumes/LaCie d2 Quadra, device: /dev/disk3s2, media: LaCie d2 quadra, interconnect: External FireWire, file system: "Journaled HFS+", OS: 10.6.4 (10F569), capacity: 749.68 GB, used: 569.83 GB, directories: 135208, files: 2494408, ejectable: YES, ACLs: Enabled
| 01:10:42 PM | Info | Copy Mode : Smart Update
| 01:10:42 PM | Info | Copy Script : Backup - all files.dset
| 01:10:42 PM | Info | Transcript : BuildTranscript.plist
| 01:10:42 PM | Info | PHASE: 1. Prepare to Copy Files
| 01:10:42 PM | Info | ...ACTION: Preparing Nick's HD
| 01:10:42 PM | Info | ......COMMAND => Verifying the integrity of volinfo.database
| 01:10:42 PM | Info | volinfo.database OK
| 01:10:42 PM | Info | ......COMMAND => Enabling permissions on Nick's HD
| 01:10:42 PM | Info | Refreshing Disk Arbitration ...
| 01:10:42 PM | Info | ......COMMAND => Verifying that permissions are enabled for Nick's HD
| 01:10:42 PM | Info | Permissions on '/' are enabled.
| 01:10:42 PM | Info | ...ACTION: Preparing LaCie d2 Quadra
| 01:10:42 PM | Info | ......COMMAND => Enabling permissions on LaCie d2 Quadra
| 01:10:42 PM | Info | Refreshing Disk Arbitration ...
| 01:10:43 PM | Info | ......COMMAND => Verifying that permissions are enabled for LaCie d2 Quadra
| 01:10:43 PM | Info | Permissions on '/Volumes/LaCie d2 Quadra' are enabled.
| 01:10:43 PM | Info | ......COMMAND => Verifying that LaCie d2 Quadra ACL support matches Nick's HD
| 01:10:43 PM | Info | ...ACTION: Preserving Spotlight state on LaCie d2 Quadra
| 01:10:43 PM | Info | ......COMMAND => Disabling Spotlight search indexing on LaCie d2 Quadra
| 01:10:43 PM | Info | PHASE: 2. Copy Files
| 01:10:43 PM | Info | ...ACTION: Copying files from Nick's HD to LaCie d2 Quadra using Smart Update
| 01:10:43 PM | Info | ......COMMAND => Cloning Nick's HD to LaCie d2 Quadra
| 01:10:44 PM | Info | Copying copy files with delete using script: /Users/Nick/Library/Application Support/SuperDuper!/Copy Scripts/Standard Scripts/Backup - all files.dset
| 01:10:44 PM | Info | Loading 27 commands from copy script /Applications/SuperDuper!.app/Contents/Resources/Copy Scripts/Exclude system temporary files.dset
| 01:10:44 PM | Info | Loading 6 commands from copy script /Applications/SuperDuper!.app/Contents/Resources/Copy Scripts/Exclude system cache files.dset
| 01:10:44 PM | Info | Loading 1 commands from copy script /Applications/SuperDuper!.app/Contents/Resources/Copy Scripts/Exclude Norton FileSaver files.dset
| 01:10:44 PM | Info | Loading 2 commands from copy script /Applications/SuperDuper!.app/Contents/Resources/Copy Scripts/Exclude Google Desktop Index files.dset
| 01:10:44 PM | Info | Loading 1 commands from copy script /Applications/SuperDuper!.app/Contents/Resources/Copy Scripts/Exclude iTunes Temporary files.dset
| 01:10:44 PM | Info | Loading 0 commands from copy script /Users/Nick/Library/Application Support/SuperDuper!/Copy Scripts/Standard Scripts/Backup - all files.dset
| 01:10:47 PM | Info | /
| 01:10:47 PM | Info | /.vol
| 01:10:47 PM | Info | Ignoring /.vol
| 01:10:47 PM | Info | /cores
| 01:10:47 PM | Info | /Network
| 01:10:47 PM | Info | /private
| 01:10:47 PM | Info | Ignoring /private/var/folders/Ei
| 01:10:47 PM | Info | Ignoring /private/var/folders/zz
| 01:10:47 PM | Info | Ignoring /private/var/folders/Gd
| 01:10:47 PM | Info | Ignoring /private/var/folders/7c
| 01:10:53 PM | Info | Ignoring /private/var/tmp/.BlankFile
| 01:10:53 PM | Info | Ignoring /private/var/tmp/BonjourPrinters.plist
| 01:10:53 PM | Info | Ignoring /private/var/tmp/Printers-CompUSA Western Digital.plist
| 01:10:53 PM | Info | Ignoring /private/var/tmp/Printers-TechTool Pro 4 DVD.plist
| 01:10:53 PM | Info | Ignoring /private/var/tmp/Printers-LaCie.plist
| 01:10:53 PM | Info | Ignoring /private/var/tmp/Printers-Seagate Barracuda.plist
| 01:10:53 PM | Info | Ignoring /private/var/tmp/Printers-Nick's HD Clone.plist
| 01:10:53 PM | Info | Ignoring /private/var/tmp/Printers-LaCie 1TB.plist
| 01:10:53 PM | Info | Ignoring /private/var/tmp/Printers-LaCie d2 Quadra.plist
| 01:10:53 PM | Info | Ignoring /private/var/tmp/com.apple.speech.synthesis.globals
| 01:10:53 PM | Info | Ignoring /private/var/tmp/launchd
| 01:10:53 PM | Info | Ignoring /private/var/vm/swapfile0
| 01:10:53 PM | Info | Ignoring /private/var/vm/swapfile2
| 01:10:53 PM | Info | Ignoring /private/var/vm/swapfile1
| 01:10:53 PM | Info | Ignoring /private/var/run/vpncontrol.sock
| 01:10:53 PM | Info | Ignoring /private/var/run/usbmuxd
| 01:10:53 PM | Info | Ignoring /private/var/run/syslog.pid
| 01:10:53 PM | Info | Ignoring /private/var/run/syslog
| 01:10:53 PM | Info | Ignoring /private/var/run/printtool
| 01:10:53 PM | Info | Ignoring /private/var/run/portmap.socket
| 01:10:53 PM | Info | Ignoring /private/var/run/mDNSResponder
| 01:10:53 PM | Info | Ignoring /private/var/run/diskarbitrationd.pid
| 01:10:53 PM | Info | Ignoring /private/var/run/cupsd
| 01:10:53 PM | Info | Ignoring /private/var/run/configd.pid
| 01:10:53 PM | Info | Ignoring /private/var/run/com.barebones.textwrangler.socket
| 01:10:53 PM | Info | Ignoring /private/var/run/com.barebones.bbedit.socket
| 01:10:53 PM | Info | Ignoring /private/var/run/com.apple.ActivityMonitor.socket
| 01:10:53 PM | Info | Ignoring /private/var/run/asl_input
| 01:10:53 PM | Info | Ignoring /private/var/run/SCHelper
| 01:10:53 PM | Info | Ignoring /private/var/run/DirectoryService.pid
| 01:10:53 PM | Info | Ignoring /private/var/run/.DSRunningSP1
| 01:10:53 PM | Info | Ignoring /private/var/run/pcscd.pub
| 01:10:53 PM | Info | Ignoring /private/var/run/macaronid.pid
| 01:10:53 PM | Info | Ignoring /private/var/run/pppconfd
| 01:10:53 PM | Info | Ignoring /private/var/run/cron.pid
| 01:10:53 PM | Info | Ignoring /private/var/run/automount.initialized
| 01:10:53 PM | Info | Ignoring /private/var/run/mds.pid
| 01:10:53 PM | Info | Ignoring /private/var/run/com.apple.loginwindow.didRunThisBoot
| 01:10:53 PM | Info | Ignoring /private/var/run/utmpx
| 01:10:53 PM | Info | Ignoring /private/var/run/mds
| 01:10:53 PM | Info | Ignoring /private/var/run/sntp.log
| 01:10:53 PM | Info | Ignoring /private/var/run/ntpd.pid
| 01:10:53 PM | Info | Ignoring /private/var/run/resolv.conf
| 01:10:53 PM | Info | Ignoring /private/var/run/.autoBackup
| 01:11:09 PM | Info | Ignoring /private/var/db/BootCache.playlist
| 01:11:09 PM | Info | Ignoring /private/var/db/volinfo.database
| 01:11:09 PM | Info | Ignoring /private/tmp/launchd-108.wasZSz
| 01:11:09 PM | Info | Ignoring /private/tmp/launch-Looaae
| 01:11:09 PM | Info | Ignoring /private/tmp/launch-C9PNFc
| 01:11:09 PM | Info | Ignoring /private/tmp/launch-3154dK
| 01:11:09 PM | Info | Ignoring /private/tmp/icssuis501
| 01:11:09 PM | Info | Ignoring /private/tmp/ics143
| 01:11:09 PM | Info | Ignoring /private/tmp/target727.indexState
| 01:11:09 PM | Info | /.Spotlight-V100
| 01:11:09 PM | Info | Preserving /.Spotlight-V100
| 01:11:09 PM | Info | /Developer
| 01:11:30 PM | Info | /.TemporaryItems
| 01:11:30 PM | Info | /Copies of Backups
| 01:12:16 PM | Info | /Users
| 01:13:07 PM | Info | Error copying /Users/Nick/Flash Drives/4.0 GB SanDisk Cruzer (BH0709JTKB)/JT's HD (Basic Backup)/Nick Naym's HD.122207/untitled folder-B:U HD/Poetry/The Interactive Raven/::
www.teachersfirst.co.pdf to /Volumes/LaCie d2 Quadra/Users/Nick/Flash Drives/4.0 GB SanDisk Cruzer (BH0709JTKB)/JT's HD (Basic Backup)/Nick Naym's HD.122207/untitled folder-B:U HD/Poetry/The Interactive Raven/::
www.teachersfirst.co.pdf of type 8 due to error 1
| 01:13:07 PM | Error | SDCopy: Error copying /Users/Nick/Flash Drives/4.0 GB SanDisk Cruzer (BH0709JTKB)/JT's HD (Basic Backup)/Nick Naym's HD.122207/untitled folder-B:U HD/Poetry/The Interactive Raven/::
www.teachersfirst.co.pdf to /Volumes/LaCie d2 Quadra/Users/Nick/Flash Drives/4.0 GB SanDisk Cruzer (BH0709JTKB)/JT's HD (Basic Backup)/Nick Naym's HD.122207/untitled folder-B:U HD/Poetry/The Interactive Raven/::
www.teachersfirst.co.pdf of type 8 due to error 1\n: Resource busy
(Continued in next post)